A large portion of the research in my lab focuses on determining anti-viral drug concentrations in PBMCs. An interesting question has come up recently, and a quick literature search did not yield any of the answers we were looking for...so I figured I'd try asking all of you fine scientists. Does anyone know, or know where to look to find average lifetimes for lymphocytes...specifically cells with CD8 or CD4, as well as B cells and monocytes?
Thanks in advance.
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This is an older review but still might be helpful..It suggests that naive T cells are long lived resting cells while memory T cells have a faster turnover rate.
ReplyDeleteLife Span of Naive and Memory T Cells
David F. Tough, Jonathan Sprent
Department of Immunology, IMM4, The Scripps Research Institute, La Jolla, California, USA
This review reports that 85% of B cells have a half-life of 5–6 weeks and the remainder have a life span of several days..
ReplyDeleteB cell life span: A review
DA FULCHER and A BASTEN
Centenary Institute of Cancer Medicine and Cell Biology. Newtown, Sydney, New South Wales, Australia
Immunology and Cell Biology (1997) 75. 446-455
Good finds, Amy! And it shows the state of the art: I have been sure forever that naive T and B cells are short-lived, while memory cells live a very long time. So maybe I've been wrong all this time. These are not easy studies to do, especially in humans.
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