Alzheimer disease and Vit E

Many lines of evidence suggest that oxidative stress is important in the pathogenesis of Alzheimer disease. In particular, b-amyloid, which is found abundantly in the brains of Alzheimer disease patients, is toxic in neuronal cell cultures through a mechanism involving free radicals. Vitamin E prevents the oxidative damage induced by b-amyloid in cell culture and delays memory deficits in animal models.