Lipoproteins and Inflammation

Lipoproteins are amphipathic molecules that encompass lipids and facilitate their transport in hydrophilic substances, such as the bloodstream. High-density lipoprotein (HDL), one of the five groups of lipoproteins, carries about 30% of blood cholesterol. High levels of HDL-bound cholesterol have been associated with a decreased risk of cardiovascular diseases, while low HDL has been linked to an increased risk for heart disease. All of the logic behind this is unknown, however the metabolic review article links this effect to its anti-inflammatory effects. Excess lipids undergo oxidation, and can induce inflammation in the liver and other organs. This can lead to many, many problems. Antioxidants and anti-inflammatory defense balance inflammation, however if overwhelmed can fail. HDL is very useful in maintaining the inflammation balance because it can increase anti-inflammatory effects and decrease genes with pro-inflammatory products, by decreasing their oxidation.

Beer Bellies Indicate a Healthy LifeStyle

During Valentine’s Day weekend up to San Diego, my family and I stopped at a rest stop called Flying J. Flying J is basically a fuel-pit-stop for many road travelers, especially truck drivers. As I stood there pumping fuel into my parent’s vehicle, I observed the many truck drivers around my surroundings.

As each individual driver was busy loading their truck with fuel, sugar loaded or caffeinated drinks, and empty calories of junk food, I thought to myself that truck drivers are the number one people who struggle with obesity. As truck drivers carry our food, cars, and clothing from one location to another, their chances of eating a healthy diet and getting enough physical activity is basically slim to none.

However, I remembered reading in Journal of Inflammation for our class discussion, claiming that obesity in relation to insulin resistance is not claimed to support an association with body mass index, visceral or subcutaneous abdominal adipose tissue, and waist circumference but rather serum C-reactive protein and fibrinogen as well as spleen longitudinal diameter representing a reliable tool in confirming insulin resistance for the obese. Therefore, does this simply mean that normal-weight people might be at higher risks of obesity than truck drivers who appear to be “9-months pregnant”?

This then concluded, as I got back behind the wheel, that if it’s really what’s on the inside that counts then a lot of people who simply appear normal-weight are in big trouble.

Link between Diabetes and Obesity

I found a very interesting article about possibly discovering a link between obesity and type II diabetes. A novel protein called pigment epithelium-derived factor (PEDF) which is released from fat cells is said to trigger the events that can lead to type II diabetes. A professor from the university states, "When PEDF is released into the bloodstream, it causes the muscles and liver to become desensitised to insulin"(Monash University). Their research shows that increasing PEDF in the blood causes diabetic reactions, but blocking PEDF reverses these actions to the point that the body starts to become responsive to insulin. Further research is still needed about this protein to eventually lead to a major breakthrough drug that can combat diabetes; but I thought this article was really cool and you all should check it out.

www.sciencedaily.com/releases/2009/07/090708090917.htm