Leptin is an important adipocytokine that acts directly on the hypothalamus, and it regulates food intake and energy expenditure. Hypoleptinemia has been linked to weight gain, fat deposition in organs, such as the liver, muscle, and pancreatic islets, clinical features of the metabolic syndrome, and a general proinflammatory state. Leptin is secreted by adipocytes and binds to receptors in the CNS, where it suppresses appetite and decreases food intake. In the peripheral tissues, it enhances
insulin sensitivity in muscle and fatty tissue, while preventing fat storage in organs such as the liver and pancreas.
It functions as a signaling factor that keeps the CNS informed on the status of energy availability in the body. Weight gain and overfeeding increase leptin expression and secretion, and reduced food intake suppresses them.
Source: Am J Med Sci 2009;X(XX):1
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Does that leave one of the possibilities for weight gain control to be leptin suppressors then? Or leptin inhibitors? I think that any possibility for keeping weight gain in check is a positive when it comes to getting DM-II under control. Most importantly thought I think people need to reevaluate their lifestyles.
ReplyDeleteI agree with you that the first step is to change the lifestyle. As far as I know cells become resistant to leptin after some time, for example, obese people produce more leptin due to the excess fat tissue, but since their cells are resistant to it, their appetite is not suppressed.
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