Serum FGF21 levels in overweight/obese subjects are significantly higher than in lean
individuals.
Serum FGF21 correlates positively with adiposity, fasting insulin, and triglycerides but negatively with HDL cholesterol . The increased risk of the metabolic
syndrome associated with high serum FGF21 is over and above the effects of individual components of the metabolic syndrome. In vitro study detected a differentiation-dependent expression of FGF21 in 3T3-L1 adipocytes and human adipocytes. In db/db obese mice, FGF21 mRNA expression was markedly increased in both the liver and adipose tissue compared with that in their lean littermates. Furthermore, FGF21 expression in subcutaneous fat correlated well with its circulating concentrations
in human.FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. Diabetes 57:1246–1253,2008
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Perhaps it would be helpful to talk about some of the terms you used in your blog (such as what FGF21 is, where it's found, what it does in general)
ReplyDeleteThen, why is this interesting to you? Why post on it?
my project is IBD and osteoporosis(to determine the klotho effects and regulation of that in inflammatory disease).
ReplyDeleteWe believe that klotho is necessary for fgf21 action and klotho expression is involved in anti inflammatory response in atherosclerosis and calcium re absorption.
Klotho is one of the hot topic that still nobody knows it's exact role.